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KMID : 0369319940140010040
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Allergy
1994 Volume.14 No. 1 p.40 ~ p.45
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Follow-up Study of Symptomatic and laboratory Change in Bronchial Asthma on Immunotherapy
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Abstract
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Allergen immunotherapy has come into widespread use since its introduction in 1911 by Noon as a treatment for pollen-induced rhinitis. It still not clear how immunotherapy produces its benefit. One of the first observed immunologic effects of
immunotherapy was the striking rise in IgG as "blocking" antibody. The tests for IgG are very expensive and therefore not very popular. So this study was performed to search for the other parameters in evaluating immunotherapy.
We selected thirty one asthmatic children who showed reactivity on allergy skin tests and specific IgE RAST. We measured clinical symptoms, allergy skin test, specific IgE RAST, and total IgE before and after immunotherapy and bronchial
hyperreactivity
with the methacholine provocation test and tried to evaluate the relationship between the laboratory changes and clinical improvements.
@ES The results as follows:
@EN 1) Symptomatic benefit was seen for asthmatic symptoms in most subjects.
2) There are no interval changes of allergy skin test.
3) Dp 8c Df-specific IgE RAST levels were decreased slightly, but HD-specific IgE RAST level was increased slightly. However, these results did not show statistical significance.
4) Total IgE level was increased slightly but was not statistically significancy.
5) There were positive findings of twenty five children(80.6% on methacholine provocation test. These findings suggested no interval changes between before and after immunotherapy on bronchial hyperreactivity.
In conclusion, this study did not show a relation between the change of allergy skin test, specific IgE RAST, and total IgE and symptomatic benifit.
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